Pegvaliase Guideline announcement

GMDI and SERN are pleased to announce that the PKU Nutrition Guideline has been updated to include recommendations for the nutrition management of patients with PKU who are treated with pegvaliase.

You can link to the PKU Nutrition Guideline here ( Under Nutrition Recommendations, Section 7, you will find evidence and consensus-based recommendations on:

  • Initiating a pegvaliase response trial
  • Monitoring
  • Managing pegvaliase treatment after response to therapy
  • Education and counseling to support normal nutrition with pegvaliase therapy
  • Pegvaliase in special populations:

Contributors include:

Nutrition Guidelines Principal Investigators
Rani Singh, PhD, RD and Fran Rohr, MS, RD

PKU Guideline Chairperson
Amy Cunningham, MS RD

PKU/Pegvaliase Workgroup Members

Heather Bausell, RD, LDN
Joyanna Hansen, PhD, RD, LD
Shideh Mofidi, MS, RD, CSP

Project Consultant,
Patricia Splett, PhD RD

Project Coordinators
Aileen Kennedy, PhD and Adrya Stembridge

 *This project is supported by the Health Resources and Services (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of an award totaling $600,000 with 5% financed with non-governmental sources (GMDI). The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by HRSA, HHS, or the U.S. Government. For more information, please visit


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